Cold Agglutinin Disease (CAD)
Cold Agglutinin Disease (CAD)
CAD is a chronic and rare blood disorder that impacts the lives of an estimated 5,000 people in the US. It is caused by antibodies called cold agglutinins binding to the surface of red blood cells, which starts a process that causes the body’s immune system to mistakenly attack healthy red blood cells and cause their rupture (hemolysis). Red blood cells have the vital job of carrying oxygen throughout the body, so people with CAD may experience severe anemia, which can result in fatigue, weakness, shortness of breath, light-headedness, chest pain, irregular heartbeat, and other potential complications